Protagonist Therapeutics (PTGX) logo

Protagonist Therapeutics (PTGX) stock

Peptide-based medicines , market cap $8.8B

$136.26
+0.26%

As of Tuesday's close · Live for Pro members at the open

Quality Score
12
Above Average
In its industry
#35of 281
Checks firing
3of 14
Choppy
From 52-week high
-15.3%
under its best in a year

PTGX's Quality Score was unchanged on Tue, Nov 10, at 12.

Follow PTGX's trial news. Pro members can get an alert when Protagonist Therapeutics files news, and see its trials, share raises, and its CEO's filings.

Get an alert when PTGX files news on its trialsSee it live, free until Thursday morning. No account. No card. Then keep going with a free account.

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NextQ1 2027“Phase 2b Program with PN-881, an Oral IL-17 Antagonist for Psoriasis, Planned to Initiate in Early Q1 2027”Trial start · SEC filing · Nov 5

Why PTGX fell on Nov 6

Down 2% on Nov 6 while the S&P 500 rose 0.3%.

  • It reported diluted EPS of $3.07 after the close on Nov 5.

Sources: Price history, Nov 6, 2026; SEC filing, Nov 5, 2026; Company release (8-K), Nov 5, 2026

1 more reason, free with an account →The other side, the timeline, and its peers, for Pro members.

Why PTGX still beats the market over three years

Up 804% over the three years to Nov 9 while the S&P 500 rose 80%; down 2% on Nov 6.

2 reasons, from its filings, with the timeline, for Pro members.

Key facts on PTGX

Key facts on PTGX
The companySales up 164% on the year
Latest filing10-Q, Nov 6 Filed its quarterly report (10-Q) for the quarter to Sep 30, 2026
1 more reason behind PTGX's 12, free with an account →3 more reasons behind PTGX's 12, for Pro members.

What's next

Thu Nov 12: Truist Securities BioPharma…Investor conference · date confirmed.

3 more dates ahead: conferences, for Pro members.

PTGX catalysts

Coming up

After its last 4 reports it closed +2.6% on average, higher 3 of 4 times.

11 past catalysts since 2021, with sizes and sources, for Pro members.

What's next for PTGX

Next step the company has named

Q1 2027“Phase 2b Program with PN-881, an Oral IL-17 Antagonist for Psoriasis, Planned to Initiate in Early Q1 2027”Trial start · SEC filing · Nov 5

What it means: when a trial begins, or reaches the stage the company named.

Lead program
PN-881

2 more trials, 26 filings, for Pro members.

Dilution on the horizon

  • Shelf registration (S-3ASR, filed Aug 6, 2025)
  • At-the-market share sales program (S-3ASR, filed Aug 6, 2025)

For Pro members: the amounts, and the share count against a year ago.

Insiders

CFO Asif Ali sold 58,629 shares on Sep 30, under a planned sale. 20 more insider trades this year.

From Form 4: open-market buys and sales only.

For Pro members: every trade, and Dinesh V’s 26 filings and quotes.

See every upcoming FDA date →

FDA dates in the next 60 days

Decision dates and advisory committee meetings the companies have announced in their filings, soonest first and small companies first.

DateStockDrug

14 more FDA dates and 103 trial data dates in the next 60 days, each on the FDA calendar. Pro members see whether each company's cash lasts past its date, with an optional alert before it. See all 151 dates, ranked →

Why PTGX scores 12

Above Averagefor quality, not price, 3 of 14 chart checks firingWhat the Quality Score means

  • +3Chart checks 3 of 14 firing right now, one point each
  • +3Growth sales up 164% on the year, operating margin up 49.5 pointsSales and margins against a year earlier: up to +3 for fast growth and widening margins, down to -2 when both shrink.
  • Long-term trend adds
  • Run-up adds
  • Profit addsRead on the last four quarters against the four before, or the last full year where no quarters are filed.
  • Persistence adds

No effect today: Size, Dilution, Volatility, Cash flow, and News.

What every line is worth, and the reason behind it, on PTGX and every other stock.Get in free →

Price, score, chart checks, and the industry rank are from a snapshot taken at 11:01 PM ET, at least 15 minutes behind. How we rank stocks.

Tested. Our top-scored stocks returned 2.2x the average stock over the next month. Reconstructed after the fact; recorded live since Sep 9, 2026. How we tested it

How PTGX ranks in Biotech

PTGX is #35 of 281 by Quality Score.

How PTGX ranks in Biotech
RankStockQuality Score
35Protagonist Therapeutics (PTGX) logoPTGXProtagonist Therapeutics12

Net income over four quarters: PTGX $342M, BHVN -$543M, SEPN -$59.0M, IRON -$243M.

More in Biotech

When does PTGX report earnings, and what happens after?

Expected to report Thu Feb 25, after the close (in 107 days).

What an earnings report is: every 3 months, a company tells everyone how much it sold and earned. We read the figures, the outlook, and how the stock moved after.

What PTGX reported on Nov 5, 2026

The quarter

A profit of $3.07 a share, from a loss of $0.62.

“This revenue was primarily driven by the proportional recognition of $266.6 million related to the $275.0 million earned from Takeda during the quarter.”

The quarter that ended Sep 30, from the company's press release

The press releaseThe filing on EDGAR

Where the sales came from

PTGX's results filing gives no sales by line in a table we read.

The outlook

No outlook figures read from this release.

In the company's words

  • “We expect our R&D expenses to increase for the remainder of the year as compared to the prior quarters in 2026.”

From its results filing (SEC filing · Nov 5)

The numbers

Market value
$8.8B
today
Sales
$552M
up 164% on the year
Free cash flow
$109M
last 12 months

Its share count grew 13% a year over 5 years.

3 more figures, for Pro members.

No analyst estimates on Breakaway: every figure here is filed.

The whole report on PTGX: every line of its sales, every outlook beside the one it replaced, and the company's words, for Pro members.

Close after the report, last 3

+4.8%+6.5%-2.4%
May 5Aug 5Nov 5
ReportedGapReaction5
days
Nov 5, 2026After close0.0%-2.4%not yet
Aug 5, 2026After close+5.6%+6.5%+10.7%
May 5, 2026After close+3.8%+4.8%+0.8%

PTGX closed higher after 3 of its last 4 reports.

All 4 reports, and PTGX's Quality Score going into each

PTGX sales and profit by year

Sales and profit by year

Sales grew in three of the last seven years, to $46M in 2025. It lost money in 2025 after a profit in 2024.

PTGX has 3 of 14 chart checks firing

Volume1 of 3 shown
Tight range1 of 3 shown
Buying1 of 3 shown
The other 10 checks on PTGX, and all 14 on every stock.Get in free →

PTGX RSI today: 45.6, below its 50-day, above its 200-day

Not scored

RSI 45.6, MACD below signal, below its 50-day, above its 200-day. Not scored.

The deep dive on PTGX

  • What it does and how it makes money4 findingsAn operating loss of $158M in fiscal 2025, on $46.0M of sales.Annual report, filed Feb 25, 2026"In 2026 and beyond, we are eligible to receive significant milestone, royalty and other payments from our collaborations with JNJ and Takeda, as described below." (10-K for fiscal 2025)SEC filing · Feb 25, 2026"Our granted U.S. patent covering rusfertide expires in 2034 but is eligible for extension of up to five years for a portion of the time spent in development." (10-K for fiscal 2025)SEC filing · Feb 25, 2026
  • Where it stands2 findingsFor Pro members2 findings on where PTGX stands: its cash, debt, and share count, for Pro members
  • What changed in its filings6 findings"In January 2020, the Company initiated arbitration proceedings with the International Court of Arbitration of the International Chamber of Commerce against Zealand related to a collaboration agreement the Company and Zealand 97 entered into in 2012 and terminated in 2014." (10-K for fiscal 2025)SEC filing · Feb 25, 2026A new heading in its "Risk Factors" this year: "Potential business combinations or other strategic transactions may disrupt our business or divert management’s attention." (10-K for fiscal 2025; not in fiscal 2024's)SEC filing · Feb 25, 2026, against the one of Feb 21, 2025One customer made up 100% of its revenue in fiscal 2025, up from 62% in fiscal 2024.SEC filing · Feb 25, 2026
  • Who holds and trades it5 findingsFor Pro members5 findings on who holds and trades PTGX, for Pro members
  • Against its closest peers4 peersNet income over four quarters: PTGX $342M, BHVN -$543M, SEPN -$59.0M, IRON -$243M.

11 more findings on PTGX, each with its source, for Pro members.

PTGX share count over time

Shares: 4.1% more than a year ago (to Sep 30).

Shares of PTGX outstanding, as filed
Shares
outstanding
As
of
65.3MOct 31, 2026
64.7MJul 31, 2026
64.3MApr 30, 2026
63.8MFeb 18, 2026
Offerings, shelves, and splits of PTGX, from its filings
From its
filings
Filed
Registered shares for a later sale (S-3ASR)Aug 6, 2025

PTGX insider trades

PTGX trades by Congress and the executive branch

2 trades disclosed in the last six months. The newest:

SellDonald Trump$15K to $50KPresident (R)traded Jul 29, disclosed Sep 22(55 days later)
All 2 trades on PTGX disclosed by Congress and the executive branch, for Pro members.Get in free →

See what Congress is buying across the market

PTGX's officers and directors

Officers and directors with a Form 4 in the last 12 months.

See insider trades by person

Which ETFs hold PTGX?

In ETFs: PTGX is under 0.1% of VTI, the most of the 24 funds Breakaway covers, by their holdings as filed for Jun 30, 2026.

About Protagonist Therapeutics

Protagonist Therapeutics Inc is a biopharmaceutical company engaged in the discovery and development of peptide-based therapeutics using its proprietary technology platform. The company focuses on three therapeutic areas: inflammation and immunology, hematology, and metabolic diseases. Its pipeline includes clinical-stage and preclinical candidates such as rusfertide for polycythemia vera, icotrokinra for inflammatory diseases, and other programs targeting IL-17, obesity, and iron metabolism disorders, developed through internal research and strategic collaborations.

141 employeesNewark, CAprotagonist-inc.com

What Protagonist Therapeutics says it competes with

“The biotechnology and pharmaceutical industries are intensely competitive and subject to rapid and significant technological change.”

From its annual report, SEC filing · Feb 25, 2026

Here is what Pro members see.

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  • 14 chart checks, read for you

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    Who reports each day, and how each stock took its last four reports.

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  • What would move PTGX's score: 4 things
  • 3 more filings explained, a plain line each
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BreakawaySep 22Donald Trump sold PTGX$15K to $50K, disclosed Sep 22

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Straight AnswersStraight Answers

As of Nov 10, 2026: PTGX's Quality Score is 12 (Above Average), #35 of 281 in Biotech.

What does PTGX's Quality Score say?

PTGX scores 12 today, which Breakaway calls Above Average. It is #35 of 281 in Biotech by Quality Score, with 3 of 14 chart checks firing. Down 2% on Nov 6 while the S&P 500 rose 0.3%. Breakaway does not say whether to buy any stock: the score does not know your situation, and it is not a recommendation to buy or sell anything. Please do your own research.

What is PTGX's Quality Score?

PTGX scores 12 today, which Breakaway calls Above Average (11 to 14). That is #35 of 281 in Biotech by Quality Score. The score adds up the chart checks, the trend, the company's filed sales, its profits, the news, insider trades, and Congress trades. The section above lists the lines behind PTGX's 12.

When does PTGX report earnings?

Expected to report Thu Feb 25, after the close, a date Breakaway expects from the company's usual timing; the company has not confirmed it. PTGX closed higher after 3 of its last 4 reports. Past behavior, not a forecast.

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What's next for Protagonist Therapeutics: from its SEC filings and ClinicalTrials.gov, the company's words, the registry's dates, and arithmetic, not a forecast. Companies often miss the dates they set.

The moves after past earnings reports are past behavior, not a forecast.

The price, the score, the chart checks and readings, and the industry rank on this page are delayed at least 15 minutes.

Our top-scored stocks' record: Oct 2021 to Sep 2026, before costs. Recorded live since Sep 9, 2026.

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