Stoke Therapeutics (STOK) logo

Stoke Therapeutics (STOK) stock

RNA medicine , market cap $1.7B

$27.21
-1.80%

As of Tuesday's close · Live for Pro members at the open

Quality Score
-2
Poor
In its industry
#165of 281
Checks firing
4of 14
Transition
From 52-week high
-32.3%
under its best in a year

STOK's Quality Score fell 1 point on Tue, Nov 10, to -2. Buying slipped from its highest in 20 days (2 chart checks stopped).

Follow STOK's trial news. Pro members can get an alert when Stoke Therapeutics files news, and see its trials, share raises, and its CEO's filings.

Get an alert when STOK files news on its trialsSee it live, free until Thursday morning. No account. No card. Then keep going with a free account.

We do the work for you. Every stock is scored and ranked, every 15 seconds while the market is open. Here it's 15 minutes behind. Pro members see it live.

NextEnd of 2026“…two cohorts, with dosing of the third cohort recently initiated and expected to complete by the end of 2026…”Trial start · SEC filing · Oct 29
Cash$359M, about 6 quarters at the last year's spendingOn Sep 30 · the company says “into early 2028”

Why STOK beats the market

Up 512% over three years while the S&P 500 rose 80%.

  • Its loss narrowed from $89.0M in fiscal 2024 to $6.9M in fiscal 2025; free cash flow went from -$35.8M to $44.9M.

Sources: Price history, Nov 9, 2026; Annual reports, Dec 31, 2025

1 more reason, free with an account →1 more reason why STOK beats the market, from its filings, with the other side, the timeline, and its peers, for Pro members.

Key facts on STOK

Key facts on STOK
Holding it backSales down 86% on the year
Latest filing10-Q, Nov 3 Filed its quarterly report (10-Q) for the quarter to Sep 30, 2026
1 more reason behind STOK's -2, free with an account →3 more reasons behind STOK's -2, for Pro members.

STOK in the news

Mon Nov 9Planet and Stoke Space Sign Multi-Launch Agreement for Nova Launch Capabilities quantisnow.com and 2 more · yesterday 9:07 AM ET STOK closed +4.4% that day.

What's next

Tue Nov 10: Guggenheim 3rd Annual Global…Investor conference · date confirmed.

1 more date ahead: the conference, for Pro members.

Cash$359M, about 6 quarters at the last year's spendingOn Sep 30 · the company says “into early 2028”

STOK catalysts

Coming up

After its last 4 reports it closed -0.8% on average, higher 2 of 4 times.

4 more coming up and 3 past catalysts since 2026, with sizes and sources, for Pro members.

What's next for STOK, and how long its cash lasts

Next step the company has named

End of 2026“Dosing is complete in the first two cohorts, with dosing of the third cohort recently initiated and expected to complete by the end of 2026.”Trial start · SEC filing · Oct 29

What it means: when a trial begins, or reaches the stage the company named.

A trial underway
Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet SyndromePhase 3 · Active · 170 people · main data estimated Mar 2027 · NCT06872125

1 more trial, 4 more milestones and 39 filings, for Pro members.

Cash runway Sep 30 balance sheet

About 6 quarters

$359M in cash and investments (as the company counts them), at its spending over the last year

What it means: how long the cash would last at the same pace, before any new money. The company's estimate is “into early 2028” (8-K, Oct 29).

For Pro members: the cash used each quarter, and the math.

Dilution on the horizon

  • Shelf registration (S-3ASR, filed Mar 18, 2026)
  • At-the-market share sales program (424B5, filed Aug 3, 2026)

For Pro members: 2 raises and their amounts, and the share count against a year ago.

Insiders

Chief Medical Officer Barry Ticho sold 7,195 shares on Nov 2, under a planned sale. 21 more insider trades this year.

From Form 4: open-market buys and sales only.

For Pro members: every trade, and Edward Kaye’s 20 filings and quotes.

See every upcoming FDA date →

FDA dates in the next 60 days

Decision dates and advisory committee meetings the companies have announced in their filings, soonest first and small companies first.

DateStockDrug

14 more FDA dates and 103 trial data dates in the next 60 days, each on the FDA calendar. Pro members see whether each company's cash lasts past its date, with an optional alert before it. See all 151 dates, ranked →

Why STOK scores -2

Poorfor quality, not price, 4 of 14 chart checks firingWhat the Quality Score means

  • +4Chart checks 4 of 14 firing right now, one point each
  • −2Growth sales down 86% on the year, operating margin down 926.3 pointsSales and margins against a year earlier: up to +3 for fast growth and widening margins, down to -2 when both shrink.
  • Long-term trend subtracts
  • Profit subtractsRead on the last four quarters against the four before, or the last full year where no quarters are filed.
  • Dilution subtractsNew shares over the year: -1 at 10% more, -2 at 25% more.
  • Cash flow subtracts-1 when free cash flow over the last four quarters is negative.

No effect today: Run-up, Size, Volatility, Persistence, News, and Insider trades.

What every line is worth, and the reason behind it, on STOK and every other stock.Get in free →

Price, score, chart checks, and the industry rank are from a snapshot taken at 10:45 PM ET, at least 15 minutes behind. How we rank stocks.

Tested. Our top-scored stocks returned 2.2x the average stock over the next month. Reconstructed after the fact; recorded live since Sep 9, 2026. How we tested it

How STOK ranks in Biotech

STOK is #165 of 281 by Quality Score.

How STOK ranks in Biotech
RankStockQuality Score
165Stoke Therapeutics (STOK) logoSTOKStoke Therapeutics-2

More in Biotech

When does STOK report earnings, and what happens after?

Expected to report Mon Mar 15, after the close (in 125 days).

What an earnings report is: every 3 months, a company tells everyone how much it sold and earned. We read the figures, the outlook, and how the stock moved after.

What STOK reported on Oct 29, 2026

The quarter

Sales of $11.3M, 6% more than a year ago; a loss of $1.08 a share, from $0.65.

“The decrease in revenue is primarily driven by the recognition of $150.8 million related to the Biogen IP license performance obligation during the nine months ended September 30, 2025.”

The quarter that ended Sep 30, from the company's press release

The press releaseThe filing on EDGAR

Where the sales came from

STOK's results filing gives no sales by line in a table we read.

The outlook

No outlook figures read from this release.

In the company's words

  • “The increase was driven by increased activities and personnel expenses to support the advancement of zorevunersen.”

From its results filing (SEC filing · Oct 29)

2 more sentences, for Pro members.

The numbers

Market value
$1.7B
today
Sales
$28.2M
down 86.3% on the year
Free cash flow
-$216M
last 12 months

Its share count grew 15% a year over 3 years.

3 more figures, for Pro members.

No analyst estimates on Breakaway: every figure here is filed.

The whole report on STOK: every line of its sales, every outlook beside the one it replaced, and the company's words, for Pro members.

Close after the report, last 4

-10.4%+0.3%+7.1%-0.2%
Jan 12May 7Aug 3Oct 29
ReportedGapReaction5
days
Oct 29, 2026After close-1.2%-0.2%-1.1%
Aug 3, 2026After close-2.6%+7.1%+9.0%
May 7, 2026After close-2.6%+0.3%-4.4%
Jan 12, 2026Before open-16.6%-10.4%-12.6%

STOK closed higher after 2 of its last 4 reports.

STOK sales and profit by year

Sales and profit by year

Sales grew in two of the last three years, to $184M in 2025. It lost money in each of the four years.

STOK has 4 of 14 chart checks firing

Volume1 of 3 shown
Tight range1 of 3 shown
Buying1 of 3 shown
The other 10 checks on STOK, and all 14 on every stock.Get in free →

STOK RSI today: 55.3, above its 50-day, below its 200-day

Not scored

RSI 55.3, MACD above signal, above its 50-day, below its 200-day. Not scored.

The deep dive on STOK

6 more findings on STOK, each with its source, for Pro members.

STOK share count over time

17% more shares than a year earlier.

Weighted shares, quarter to Sep 30, 2026, both from one filing

Shares of STOK outstanding, as filed
Shares
outstanding
As
of
65.4MOct 30, 2026
64.5MJul 30, 2026
62.3MApr 30, 2026
59.2MFeb 28, 2026
Offerings, shelves, and splits of STOK, from its filings
From its
filings
Filed
Set up an at-the-market program for up to $200M of shares, about 12% of its market valueAug 3, 2026
Registered shares for a later sale (S-3ASR)Mar 18, 2026
Registered shares for a later sale (S-3)Jul 9, 2025
Registered shares for a later sale (S-3ASR)Oct 9, 2024

STOK insider trades

3 insiders sold $647K across 6 filings in the last 6 months. No open-⁠market buys on record. The newest:

SellEdward M. Kaye$382KDirectorat $32.01 on Aug 18, filed Aug 18

All 6 insider filings on STOK from the last six months, for Pro members.

STOK's officers and directors

Officers and directors with a Form 4 in the last 12 months.

See insider trades by person

Which ETFs hold STOK?

In ETFs: STOK is under 0.1% of VTI, the most of the 24 funds Breakaway covers, by their holdings as filed for Jun 30, 2026.

About Stoke Therapeutics

Stoke Therapeutics Inc is a biotechnology company dedicated to restoring protein expression by harnessing the bodys potential with RNA medicine. Its proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to restore naturally-occurring protein levels selectively. Its first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome. The company provides early programs focused on multiple targets, including haploinsufficiency diseases of the central nervous system and eye, to up-regulate the protein expression of the underlying disease gene in a mutation-agnostic manner.

170 employeesBedford, MAstoketherapeutics.com

What Stoke Therapeutics says it competes with

“The biotechnology and biopharmaceutical industries, and the genetic medicines fields, are characterized by rapid evolution of technologies, fierce competition and strong defense of intellectual property.”

From its annual report, SEC filing · Mar 16, 2026

Here is what Pro members see.

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  • Every line of the score

    Price action, the company, and signals, each with its points, on STOK and every other stock.

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    Each date in the company's words, its cash against the date, and an optional alert before it.

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  • Congress trades

    A member's trades, newest first, each with its amount. Sort and filter the whole list.

  • 14 chart checks, read for you

    The ones firing on the stock, each in plain words, its rule a tap away.

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    Who reports each day, and how each stock took its last four reports.

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    Every stock a box, colored by its Quality Score.

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    Each theme's stocks ranked by Quality Score, live. Here, AI chips.

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    The ten highest Quality Scores at each close, kept day by day, week by week.

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Pro members see every line of every stock's score.

  • What would turn STOK's score around: 8 things
  • 9 more filings explained, a plain line each
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BreakawayAug 18Edward M. Kaye sold STOK$382K at $32.01, filed Aug 18

Alerts are optional.

See STOK's 14 chart checks

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Straight AnswersStraight Answers

As of Nov 10, 2026: STOK's Quality Score is -2 (Poor), #165 of 281 in Biotech. Insiders sold $647K in the last 6 months (Form 4).

What does STOK's Quality Score say?

STOK scores -2 today, which Breakaway calls Poor. It is #165 of 281 in Biotech by Quality Score, with 4 of 14 chart checks firing. Up 512% over three years while the S&P 500 rose 80%. Cash lasts about 6 quarters at its spending (to Sep 30). Breakaway does not say whether to buy any stock: the score does not know your situation, and it is not a recommendation to buy or sell anything. Please do your own research.

What is STOK's Quality Score?

STOK scores -2 today, which Breakaway calls Poor (below zero). That is #165 of 281 in Biotech by Quality Score. The score adds up the chart checks, the trend, the company's filed sales, its profits, the news, insider trades, and Congress trades. The section above lists the lines behind STOK's -2.

Are insiders buying STOK?

3 insiders sold $647K across 6 filings in the last 6 months. No open-⁠market buys on record. The newest is Edward M. Kaye, Director, who sold $382K on Aug 18. Every filing, with the scored weight, for Pro members.

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Only on the public pages, which run at least 15 minutes behind. Pro members, and anyone on a guest pass, see real-time prices: the scanner refreshes every 15 seconds, and your watchlist every few seconds, pre-market and after hours included.

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What's next for Stoke Therapeutics: from its SEC filings and ClinicalTrials.gov, the company's words, the registry's dates, and arithmetic, not a forecast. Companies often miss the dates they set.

The moves after past earnings reports are past behavior, not a forecast.

The price, the score, the chart checks and readings, and the industry rank on this page are delayed at least 15 minutes.

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