Ultragenyx Pharmaceutical (RARE) logo

Ultragenyx Pharmaceutical (RARE) stock

Rare disease medicines , market cap $1.6B

$16.14
-1.65%

As of Tuesday's close · Live for Pro members at the open

Quality Score
-2
Poor
In its industry
#171of 281
Checks firing
4of 14
Choppy
From 52-week high
-59.5%
under its best in a year

RARE's Quality Score was unchanged on Tue, Nov 10, at -2.

Follow RARE's trial news. Pro members can get an alert when Ultragenyx Pharmaceutical files news, and see its trials, share raises, and its CEO's filings.

Get an alert when RARE files news on its trialsSee it live, free until Thursday morning. No account. No card. Then keep going with a free account.

We do the work for you. Every stock is scored and ranked, every 15 seconds while the market is open. Here it's 15 minutes behind. Pro members see it live.

Next2H 2026“…in other genotypes and ages, began in October 2025 and is expected to complete in the second half of 2026…”Trial start · SEC filing · Aug 4
Cash$401M, about 3 quarters at the last year's spendingOn Sep 30

Why is RARE down?

Down 55% from its Dec 4, 2025 high.

  • Its pretax margin went from -68.4% in fiscal 2020 to -84.8% in fiscal 2025; its 2 peers' median rose 51.4 points.

Sources: Price history, Nov 9, 2026; Annual reports, Dec 31, 2025; Peers' annual reports, Nov 9, 2026

1 more reason, free with an account →1 more reason why RARE is down from its high, from its filings, with the other side, the timeline, and its peers, for Pro members.

Key facts on RARE

Key facts on RARE
Since its Dec 2021 highDown 81% sales $351.4M → $730M a year
Latest filing10-Q, Nov 4 Filed its quarterly report (10-Q) for the quarter to Sep 30, 2026
1 more reason behind RARE's -2, free with an account →4 more reasons behind RARE's -2, for Pro members.

RARE in the news

Wed Nov 4Ultragenyx cuts 20% of staff and ends Wilson disease gene therapy as it targets 2027 profitability the pharma letter and 1 more · yesterday 3:15 PM ET RARE closed +3.2% that day.

Cash$401M, about 3 quarters at the last year's spendingOn Sep 30

RARE catalysts

Coming up

After its last 4 reports it closed -2.3% on average, higher 2 of 4 times.

3 more coming up and 27 past catalysts since 2018, with sizes and sources, for Pro members.

What's next for RARE, and how long its cash lasts

Next step the company has named

2H 2026“Enrollment in the open-label Phase 2/3 Aurora study, evaluating GTX-102 in other genotypes and ages, began in October 2025 and is expected to complete in the second half of 2026.”Trial start · SEC filing · Aug 4

What it means: when a trial begins, or reaches the stage the company named.

Lead program
GTX-102
Another trial
Setrusumab in Pediatric Japanese Subjects With Osteogenesis ImperfectaPhase 3 · Active · 6 people · main data estimated Jan 2027 · NCT06636071

8 more trials, 52 filings, for Pro members.

Cash runway Sep 30 balance sheet

About 3 quarters

$401M in cash and investments (as the company counts them), at its spending over the last year

What it means: how long the cash would last at the same pace, before any new money.

For Pro members: the cash used each quarter, and the math.

Dilution on the horizon

No shelf registration or at-the-market program on file in the last three years.

For Pro members: 1 raise and its amount, and the share count against a year ago.

Insiders

CFO Howard Horn sold 7,066 shares on Oct 15. 22 more insider trades this year.

From Form 4: open-market buys and sales only.

For Pro members: every trade, and Emil Kakkis’s 6 filings and quotes.

See every upcoming FDA date →

FDA dates in the next 60 days

Decision dates and advisory committee meetings the companies have announced in their filings, soonest first and small companies first.

DateStockDrug

14 more FDA dates and 103 trial data dates in the next 60 days, each on the FDA calendar. Pro members see whether each company's cash lasts past its date, with an optional alert before it. See all 151 dates, ranked →

Why RARE scores -2

Poorfor quality, not price, 4 of 14 chart checks firingWhat the Quality Score means

  • +4Chart checks 4 of 14 firing right now, one point each
  • −3Long-term trend below a falling 200-⁠day average, down over one year, down over two years
  • Profit subtractsRead on the last four quarters against the four before, or the last full year where no quarters are filed.
  • Growth addsSales and margins against a year earlier: up to +3 for fast growth and widening margins, down to -2 when both shrink.
  • Volatility subtractsA daily range of 5% or more with nothing behind it (no profit or cash flow, sales shrinking, or 10% more shares outstanding with no free cash flow): -1, or -2 from 8%.
  • Cash flow subtracts-1 when free cash flow over the last four quarters is negative.
  • Insider trades subtracts

No effect today: Run-up, Size, Dilution, Persistence, and News.

What every line is worth, and the reason behind it, on RARE and every other stock.Get in free →

Price, score, chart checks, and the industry rank are from a snapshot taken at 11:01 PM ET, at least 15 minutes behind. How we rank stocks.

Tested. Our top-scored stocks returned 2.2x the average stock over the next month. Reconstructed after the fact; recorded live since Sep 9, 2026. How we tested it

How RARE ranks in Biotech

RARE is #171 of 281 by Quality Score.

How RARE ranks in Biotech
RankStockQuality Score
171Ultragenyx Pharmaceutical (RARE) logoRAREUltragenyx Pharmaceutical-2

More in Biotech

When does RARE report earnings, and what happens after?

Expected to report Tue Feb 9, after the close (in 91 days).

What an earnings report is: every 3 months, a company tells everyone how much it sold and earned. We read the figures, the outlook, and how the stock moved after.

What RARE reported on Nov 3, 2026

The quarter

Sales of $173.0M, 8% more than a year ago; a loss of $1.16 a share, from $1.81.

“EVKEEZA® revenue in the third quarter 2026 was $24 million, driven by increased demand from new country launches and early access.”

The quarter that ended Sep 30, from the company's press release

The press releaseThe filing on EDGAR

Where the sales came from

Where the quarter's sales came from
LineQ3
2026
Q2
2026
Q3
2025
By product
Productup 11%$105M61%$112M52%$95M59%

Each quarter's sales and their share of its total. Figures as filed (SEC filing, Nov 4)

5 more lines, for Pro members.

The outlook

The outlook the company gave, by period
MeasureFigure
Full year 2026
Total revenue$730M to $760Mkept

Figures as filed (SEC filing, Nov 3)

5 more outlook lines, for Pro members.

In the company's words

  • “The company continues to anticipate achieving full-year GAAP profitability in 2027 and going forward.”

From its results filing (SEC filing · Nov 3)

1 more sentence, for Pro members.

The numbers

Market value
$1.6B
today
Sales
$730M
up 15.8% on the year
Free cash flow
-$442M
last 12 months

Sales grew 20% a year over 5 years, fiscal 2020 to 2025.

Its share count grew 10% a year over 5 years.

2 more figures, for Pro members.

No analyst estimates on Breakaway: every figure here is filed.

The whole report on RARE: every line of its sales, every outlook beside the one it replaced, and the company's words, for Pro members.

Close after the report, last 3

+3.7%-3.4%+3.2%
May 5Aug 4Nov 3
ReportedGapReaction5
days
Nov 3, 2026After close+2.5%+3.2%-3.0%
Aug 4, 2026After close+10.3%-3.4%+4.5%
May 5, 2026After close+3.6%+3.7%+7.3%

RARE closed higher after 2 of its last 4 reports.

All 4 reports, and RARE's Quality Score going into each

RARE sales and profit by year

Sales and profit by year

Sales grew every year from 2018 to 2025, to $673M. It lost money in each of the eight years.

RARE has 4 of 14 chart checks firing

Volume1 of 3 shown
Tight range1 of 3 shown
Buying1 of 3 shown
The other 10 checks on RARE, and all 14 on every stock.Get in free →

RARE RSI today: 49.9, above its 50-day, below its 200-day

Not scored

RSI 49.9, MACD above signal, above its 50-day, below its 200-day. Not scored.

The deep dive on RARE

11 more findings on RARE, each with its source, for Pro members.

RARE share count over time

2% more shares than a year earlier.

Weighted shares, quarter to Sep 30, 2026, both from one filing

Shares of RARE outstanding, as filed
Shares
outstanding
As
of
101.9MOct 29, 2026
98.6MJul 31, 2026
98.5MMay 1, 2026
96.6MFeb 13, 2026
Offerings, shelves, and splits of RARE, from its filings
From its
filings
Filed
Raised $290M in a sale of shares, about 18% of its market valueJun 14, 2024
Registered shares for a later sale (S-3ASR)Feb 21, 2024

RARE insider trades

3 insiders sold $160K across 3 filings in the last 6 months. No open-⁠market buys on record. The newest:

SellHoward Horn$108KChief Financial Officerat $15.27 on Oct 15, filed Oct 19

All 3 insider filings on RARE from the last six months, for Pro members.

All RARE insider trades

RARE trades by Congress and the executive branch

One trade disclosed in the last six months. The newest:

BuyGilbert Cisneros$1K to $15KHousetraded Sep 29, disclosed Oct 12(13 days later)

See what Congress is buying across the market

RARE's officers and directors

Officers and directors with a Form 4 in the last 12 months.

8 more officers and directors file at RARE.

See insider trades by person

Which ETFs hold RARE?

In ETFs: RARE is under 0.1% of VTI, the most of the 24 funds Breakaway covers, by their holdings as filed for Jun 30, 2026.

About Ultragenyx Pharmaceutical

Ultragenyx Pharmaceutical Inc is a USA-based biopharmaceutical company. The company identifies, acquires, develops, and commercializes novel products for the treatment of serious, rare, and ultra-rare diseases, with a focus on debilitating genetic conditions. Its medicine portfolio includes Crysvita, Dojolvi, and Mepsevii. Crysvita is indicated for the treatment of X-linked hypophosphatemia (XLH) in adult and pediatric patients aged one year and older. Mepsevii is indicated for pediatric and adult patients for the treatment of Mucopolysaccharidosis VII. The company operates across North America, Latin America, Europe, the Middle East and Africa, and Asia-Pacific, with the majority of its revenue generated from North America.

1,371 employeesNovato, CAultragenyx.com

What Ultragenyx Pharmaceutical says it competes with

“With respect to Crysvita, although we are not aware of any other products currently in clinical development by a competitor for the treatment of XLH and TIO, it is possible that competitors may produce, develop, and commercialize therapeutics, or utilize other approaches such as gene therapy, to treat XLH and TIO.”

From its annual report, SEC filing · Feb 18, 2026

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  • What would turn RARE's score around: 8 things
  • 7 more filings explained, a plain line each
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BreakawayOct 12Gilbert Cisneros bought RARE$1K to $15K, disclosed Oct 12

Alerts are optional.

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Straight AnswersStraight Answers

As of Nov 10, 2026: RARE's Quality Score is -2 (Poor), #171 of 281 in Biotech. Insiders sold $160K in the last 6 months (Form 4).

What does RARE's Quality Score say?

RARE scores -2 today, which Breakaway calls Poor. It is #171 of 281 in Biotech by Quality Score, with 4 of 14 chart checks firing. Down 55% from its Dec 4, 2025 high. Cash lasts about 3 quarters at its spending (to Sep 30). Breakaway does not say whether to buy any stock: the score does not know your situation, and it is not a recommendation to buy or sell anything. Please do your own research.

What is RARE's Quality Score?

RARE scores -2 today, which Breakaway calls Poor (below zero). That is #171 of 281 in Biotech by Quality Score. The score adds up the chart checks, the trend, the company's filed sales, its profits, the news, insider trades, and Congress trades. The section above lists the lines behind RARE's -2.

Are insiders buying RARE?

3 insiders sold $160K across 3 filings in the last 6 months. No open-⁠market buys on record. The newest is Howard Horn, Chief Financial Officer, who sold $108K on Oct 15. Every filing, with the scored weight, for Pro members.

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What's next for Ultragenyx Pharmaceutical: from its SEC filings and ClinicalTrials.gov, the company's words, the registry's dates, and arithmetic, not a forecast. Companies often miss the dates they set.

The moves after past earnings reports are past behavior, not a forecast.

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