Fulcrum Therapeutics (FULC) logo

Fulcrum Therapeutics (FULC) stock

Rare disease medicines , market cap $281M

$3.72
0.00%

As of Tuesday's close · Live for Pro members at the open

Quality Score
-2
Poor
In its industry
#168of 281
Checks firing
4of 14
Choppy
From 52-week high
-76.4%
under its best in a year

FULC's Quality Score fell 1 point on Tue, Nov 10, to -2. It did not trade higher than the day before.

Follow FULC's news. Pro members can get an alert when Fulcrum Therapeutics files news, and see its trials, share raises, and its CEO's filings.

Get an alert when FULC files newsSee it live, free until Thursday morning. No account. No card. Then keep going with a free account.

We do the work for you. Every stock is scored and ranked, every 15 seconds while the market is open. Here it's 15 minutes behind. Pro members see it live.

Next2H 2027“…P2 initiation strong preclinical data SLTE-2100 and undisclosed 1H 2026 Mid-year 2026 Mid-year 2027 2H 2027…”Trial data · SEC filing · Aug 17

Why does FULC lag the market?

Up 10% over three years while the S&P 500 rose 80%.

  • Its loss grew to $74.9M in fiscal 2025, and it filed a prospectus for an offering of shares on Nov 4, 2026.

Sources: Price history, Nov 9, 2026; Annual reports, Dec 31, 2025; Prospectus supplement, Nov 4, 2026

1 more reason, free with an account →1 more reason why FULC lags the market, from its filings, with the other side, how the business stands, the timeline, and its peers, for Pro members.

Key facts on FULC

Key facts on FULC
Since its 2022 highDown 85% sales $19.2M → $0 a year
Latest filing10-Q, Jul 30 Filed its quarterly report (10-Q) for the quarter to Jun 30, 2026
1 more reason behind FULC's -2, free with an account →3 more reasons behind FULC's -2, for Pro members.

FULC in the news

ReportExpected to report Monday, before the open. Every 3 months, a company tells everyone how much it sold and earned. It fell after 3 of its last 3 reports, -9.7% on average. Past reports ›

FULC catalysts

Coming up

After its last 3 reports it closed -9.7% on average, higher 0 of 3 times.

What's next for FULC, and how long its cash lasts

Next step the company has named

2H 2027“study expected and P2 initiation strong preclinical data SLTE-2100 and undisclosed 1H 2026 Mid-year 2026 Mid-year 2027 2H 2027 program expected to be announced in Healthy volunteer PK has…”Trial data · SEC filing · Aug 17

What it means: the first look at a trial’s main results, as the company reports them.

Lead program
SLTE-2100

For Pro members: 29 filings.

Cash runway

The company says its cash lasts into 2029 (8-K, Aug 17).

That is the company's estimate. Our arithmetic on its latest balance sheet reads differently, so we show its words, not ours.

For Pro members: the cash on hand, the cash used each quarter, and the math.

Dilution on the horizon

  • Shelf registration (S-3, filed Feb 27, 2024)
  • At-the-market share sales program (S-3, filed Feb 27, 2024)

For Pro members: 2 raises and their amounts, and the share count against a year ago.

Insiders

Director Alan Ezekowitz sold 18,000 shares on Jun 26. 2 more insider trades this year.

From Form 4: open-market buys and sales only.

For Pro members: every trade, and Alex Sapir’s 2 filings and quotes.

Get an alert when FULC files newsA free account. No card.

See every upcoming FDA date →

FDA dates in the next 60 days

Decision dates and advisory committee meetings the companies have announced in their filings, soonest first and small companies first.

DateStockDrug

14 more FDA dates and 103 trial data dates in the next 60 days, each on the FDA calendar. Pro members see whether each company's cash lasts past its date, with an optional alert before it. See all 151 dates, ranked →

Why FULC scores -2

Poorfor quality, not price, 4 of 14 chart checks firingWhat the Quality Score means

  • +4Chart checks 4 of 14 firing right now, one point each
  • −2Long-term trend below a falling 200-⁠day average, down over one year
  • Size subtracts
  • Profit subtractsRead on the last four quarters against the four before, or the last full year where no quarters are filed.
  • Dilution subtractsNew shares over the year: -1 at 10% more, -2 at 25% more.
  • Cash flow subtracts-1 when free cash flow over the last four quarters is negative.

No effect today: Run-up, Growth, Volatility, Persistence, and News.

What every line is worth, and the reason behind it, on FULC and every other stock.Get in free →

Price, score, chart checks, and the industry rank are from a snapshot taken at 10:56 PM ET, at least 15 minutes behind. How we rank stocks.

Tested. Our top-scored stocks returned 2.2x the average stock over the next month. Reconstructed after the fact; recorded live since Sep 9, 2026. How we tested it

How FULC ranks in Biotech

FULC is #168 of 281 by Quality Score.

How FULC ranks in Biotech
RankStockQuality Score
168Fulcrum Therapeutics (FULC) logoFULCFulcrum Therapeutics-2

More in Biotech

When does FULC report earnings, and what happens after?

Expected to report Mon Nov 16, before the open (in 6 days).

What an earnings report is: every 3 months, a company tells everyone how much it sold and earned. We read the figures, the outlook, and how the stock moved after.

What FULC reported on Apr 27, 2026

The quarter

The figures are not read from the release yet.

“The decrease of $19.0 million was primarily due to cash used to fund operating activities in 2026.”

The filing on EDGAR

Where the sales came from

FULC's results filing gives no sales by line in a table we read.

The outlook

No outlook figures read from this release.

In the company's words

  • “The increase of $0.7 million was primarily due to higher employee compensation costs, including $0.4 million of increased stock-based compensation expense.”

From its results filing (SEC filing · Apr 27)

1 more sentence, for Pro members.

The numbers

Market value
$281M
today

No analyst estimates on Breakaway: every figure here is filed.

The whole report on FULC: every line of its sales, every outlook beside the one it replaced, and the company's words, for Pro members.

Close after the report, last 3

-6.4%-21.2%-1.5%
Oct 29Feb 24Apr 27
ReportedGapReaction5
days
Apr 27, 2026Before open-4.5%-1.5%-6.1%
Feb 24, 2026Before open-11.4%-21.2%-28.3%
Oct 29, 2025Before open-2.8%-6.4%-16.3%

FULC closed higher after 0 of its last 3 reports.

Everyone reporting earnings next week

FULC sales and profit by year

Sales and profit by year

Sales grew in two of the last five years, to $0 in 2025. It lost money in each of the six years.

FULC has 4 of 14 chart checks firing

Volume1 of 3 shown
Tight range1 of 3 shown
Buying1 of 3 shown
The other 10 checks on FULC, and all 14 on every stock.Get in free →

FULC RSI today: 50.4, below its 50-day and 200-day averages

Not scored

RSI 50.4, MACD above signal, below both averages. Not scored.

The deep dive on FULC

  • What it does and how it makes money1 findingFor Pro members1 finding on what FULC does and how it makes money, for Pro members
  • What changed in its filings1 findingA new heading in its "Risk Factors" this year: "Our use of new and evolving technologies, such as artificial intelligence, or AI, may present risks and challenges that can impact our business, including by posing cybersecurity and other risks to our confidential and/or proprietary information …" (10-K for fiscal 2025; not in fiscal 2024's)SEC filing · Feb 24, 2026, against the one of Feb 25, 2025
  • Who holds and trades it2 findingsNo open-market trades by insiders in 90 days; the last on file, 10% owner Kevin Tang bought $179K on Jul 17, 2026.Form 4, filed Jul 20, 2026

FULC share count over time

Shares: 22.0% more than a year ago (to Dec 31).

Shares of FULC outstanding, as filed
Shares
outstanding
As
of
76.3MJul 23, 2026
66.6MApr 20, 2026
66.6MFeb 17, 2026
54.1MOct 22, 2025
Offerings, shelves, and splits of FULC, from its filings
From its
filings
Filed
Priced a sale of sharesNov 4, 2026
Raised $160M in a sale of shares, about 57% of its market valueDec 11, 2025
Registered shares for a later sale (S-3)Feb 27, 2024

FULC insider trades

One insider bought $1.5M across 6 filings, and one insider sold $66K across 1 filing, in the last 6 months. The newest:

BuyKevin Tang$415K10% ownerat $3.56 on Jul 16, filed Jul 20

All 7 insider filings on FULC from the last six months, for Pro members.

All FULC insider trades

FULC's officers and directors

Officers and directors with a Form 4 in the last 12 months.

See insider trades by person

Which ETFs hold FULC?

In ETFs: FULC is under 0.1% of VTI, the most of the 24 funds Breakaway covers, by their holdings as filed for Jun 30, 2026.

About Fulcrum Therapeutics

Fulcrum Therapeutics Inc is a clinical-stage biopharmaceutical company focused on developing small molecules for genetically defined rare diseases. Its product candidate, Pociredir, is an oral small molecule designed to induce fetal hemoglobin (HbF) and is in clinical development for sickle cell disease (SCD). The company completed dosing in the Phase 1b PIONEER trial evaluating pociredir in adults with SCD and reported clinical data showing clinically relevant HbF induction and improvements in markers of hemolysis and anemia. The company has also generated a pipeline of clinical-stage and pre-clinical programs targeting the root causes of rare genetic diseases.

55 employeesCambridge, MAfulcrumtx.com

What Fulcrum Therapeutics says it competes with

“The biotechnology and pharmaceutical industries are characterized by rapidly advancing technologies, intense competition and a strong emphasis on proprietary products.”

From its annual report, SEC filing · Feb 24, 2026

Here is what Pro members see.

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  • Congress trades

    A member's trades, newest first, each with its amount. Sort and filter the whole list.

  • 14 chart checks, read for you

    The ones firing on the stock, each in plain words, its rule a tap away.

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    Who reports each day, and how each stock took its last four reports.

  • The market map

    Every stock a box, colored by its Quality Score.

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Pro members see every line of every stock's score.

  • What would turn FULC's score around: 7 things
  • 4 more filings explained, a plain line each
  • Real-⁠time prices, no delay
BreakawayJul 20Kevin Tang bought FULC$415K at $3.56, filed Jul 20

Alerts are optional.

See FULC's 14 chart checks

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Straight AnswersStraight Answers

As of Nov 10, 2026: FULC's Quality Score is -2 (Poor), #168 of 281 in Biotech. Insiders bought $1.5M and sold $66K in the last 6 months (Form 4).

What does FULC's Quality Score say?

FULC scores -2 today, which Breakaway calls Poor. It is #168 of 281 in Biotech by Quality Score, with 4 of 14 chart checks firing. Up 10% over three years while the S&P 500 rose 80%. Shares: 22.0% more than a year ago (to Dec 31). Breakaway does not say whether to buy any stock: the score does not know your situation, and it is not a recommendation to buy or sell anything. Please do your own research.

What is FULC's Quality Score?

FULC scores -2 today, which Breakaway calls Poor (below zero). That is #168 of 281 in Biotech by Quality Score. The score adds up the chart checks, the trend, the company's filed sales, its profits, the news, insider trades, and Congress trades. The section above lists the lines behind FULC's -2.

Are insiders buying FULC?

One insider bought $1.5M across 6 filings, and one insider sold $66K across 1 filing, in the last 6 months. The newest is Kevin Tang, 10% owner, who bought $415K on Jul 16. Every filing, with the scored weight, for Pro members.

Are the prices delayed?

Only on the public pages, which run at least 15 minutes behind. Pro members, and anyone on a guest pass, see real-time prices: the scanner refreshes every 15 seconds, and your watchlist every few seconds, pre-market and after hours included.

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What's next for Fulcrum Therapeutics: from its SEC filings and ClinicalTrials.gov, the company's words, the registry's dates, and arithmetic, not a forecast. Companies often miss the dates they set.

The moves after past earnings reports are past behavior, not a forecast.

The price, the score, the chart checks and readings, and the industry rank on this page are delayed at least 15 minutes.

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