Denali Therapeutics (DNLI) stock

Market cap $3.3B

$20.53
-0.68%

Market closed. Prices as of Thursday's close.

Quality Score
-2
Poor
In its industry
#164of 276
NextEnd of 2026“…now expects results from the study in 2027, updated from its prior expectation of results by the end of 2026…”Trial data · 8-K, Aug 6
Cash$940M, about 8 quarters (2 years) at the last year's spendingOn Jun 30

Follow DNLI's trial news. Pro members can get an alert when Denali Therapeutics files news, and see its trials, share raises, and its CEO's filings.

Get an optional alert when DNLI files news on its trialsFree for 24 hours. No account needed.
Cash$940M, about 8 quarters (2 years) at the last year's spendingOn Jun 30
Pipeline and cash

What's next for DNLI, and how long its cash lasts

From Denali Therapeutics’s SEC filings and ClinicalTrials.gov: the company’s own words, the registry’s dates, and arithmetic, not a forecast. Companies often miss their own dates.

Next step the company has named

End of 2026“Denali now expects results from the study in 2027, updated from its prior expectation of results by the end of 2026.”Trial data · 8-K, Aug 6

What it means: the first look at a trial’s main results, as the company reports them.

A trial underway
Extension Study of the Long-Term Safety, Tolerability, and Efficacy of Tividenofusp Alfa in Participants With Mucopolysaccharidosis Type II (MPS II) From Study DNLI-E-0002 or Study DNLI-E-0007Phase 2/3 · By invitation · 99 people · main data estimated Jun 2027 · NCT06075537

8 more trials, 1 with data due this year, 3 more milestones and 36 filings, for Pro members.

Cash runway Jun 30 balance sheet

About 8 quarters

$940M in cash and investments (the company's own count), at its spending over the last year

What it means: how long the cash would last at the same pace, before any new money.

For Pro members: the cash used each quarter, and the math.

Dilution on the horizon

  • Shelf registration (S-3ASR, filed Feb 27, 2025)
  • At-the-market share sales program (S-3ASR, filed Feb 27, 2025)

A shelf lets a company sell shares later; an at-the-market program sells them into the market over time. Neither is a sale by itself.

For Pro members: 1 raise and its amount, and the share count against a year ago.

Insiders

Chief Medical Officer Peter Scott Chin sold 1,654 shares on Sep 4. 5 more insider trades this year.

From their own Form 4 filings: buys and sales in the market, not awards or shares withheld for tax.

For Pro members: every trade, and Ryan Watts’s 16 filings and quotes.

See every upcoming FDA date →

Biotech dates

FDA dates in the next 60 days

Decision dates and advisory committee meetings the companies have announced in their own filings, soonest first and small companies first.

DateStockDrug

8 more FDA dates and 107 trial data dates in the next 60 days. Pro members see every one, with the cash against its date and an optional alert before it. Get in free →

Why it's down

Down 20% in 3 months, 10% under its 50-day average. Down 59% over 5 years, while the S&P 500 rose 78%.

Down more than its industry: the 275 other stocks in it fell a median 11% over the same 3 months.

−2Long-term trend below a falling 200-day average, down over two years

2 more things pulling DNLI's score down, for Pro members

What's next

Expected to report Thu Nov 5, after the close

After its last 4 reports it closed +0.8% on average, higher 2 of 4 times.

What would turn DNLI's score around: 6 things, for Pro members

Alert me when DNLI's Quality Score turns up

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Pro

Here is what Pro members see.

Every stock gets a card like this one, and a page with its price in real time, every line of its score, the chart, and its filings.

A Pro member's scanner card for AMD: the Quality Score badge, the rank in the scan and in its industry, the chart checks bar, three plain lines on its strength, notable holders, and early signs, and pills for size, volume, RSI, and short interest
A card on the scanner, shown on AMD
A Pro member's stock page for AMD: the Quality Score with its rank, the checks firing, and the reason behind it, the live price, and the chart
A stock page
The scanner a Pro member sees: every stock as a card with its Quality Score, rank, and chart checks bar, and the watchlist
The scanner
The 14 checks

DNLI has 2 of 14 checks firing

One per group is shown here.

Trend1 of 5 shown

Averages stacked in order, price near its high.

Volume1 of 3 shown

Heavy volume on the run, quiet volume at rest.

Tight range1 of 3 shown

The daily range is tight against its own recent history.

Buying1 of 3 shown

Closes near the high, and buyers step in on dips.

The other 10 checks on DNLI, and all 14 on every stock.Get in free →

Also on the chart

Not scored

Shown for reference. None of these counts toward the Quality Score: in our tests on 20 years of daily prices, none of them improved it.

  • RSI 1440.0

    Above 30, below 50.

  • MACD (12, 26, 9)Above signal

    Crossed above its signal line 3 sessions ago.

  • The price is 10.5% below it.

  • The price is 2.4% below it. The 50-day is above the 200-day, since Nov 17, 2025.

  • ADX 1425.8

    25 or more, with +DI below -DI.

  • Support$19.40

    Swing low from Sep 21, 5.5% below the price.

  • Swing high from May 11, 0.1% above the price.

  • The bands run from $19.40 to $22.52.

  • Volume1.1x

    Against its 20-day average, for the time of day.

Its industry

How DNLI ranks in Biotech

DNLI is #164 of 276 by Quality Score. The top three are shown with their scores, and more by name.

More in Biotech, on the Healthcare page

Earnings

When does DNLI report earnings, and what happens after?

Expected to report Thu Nov 5, after the close (in 34 days). Not yet confirmed by the company.

ReportedGapReaction5 sessions
Aug 6, 2026After close+2.8%+0.4%+0.4%
May 7, 2026After close-1.4%-0.5%-1.6%
Feb 26, 2026After close-1.3%-1.1%-8.0%
Nov 6, 2025After close+1.0%+4.2%+19.0%

The gap is the next open against the close before the report; the reaction is where that session closed. DNLI closed higher after 2 of its last 4. Past behavior, not a forecast.

Report dates and past reactions come from sessions that have already closed, so none of these figures move.

Filings

Who is trading DNLI

DNLI insider trades

2 insiders sold $108K across 2 filings in the last 6 months. No open-⁠market buys on record. The newest:

SellPeter Scott Chin$37KChief Medical Officerat $22.29 on Sep 4, filed Sep 9
All 2 insider filings on DNLI from the last six months, for Pro members.Get in free →

An insider has two business days to file a Form 4, so the trade is already days old when it becomes public. Shown as filed, with no delay.

The company

About Denali Therapeutics

Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.

507 employeesSouth San Francisco, CAdenalitherapeutics.com

Pro

Every line of the score, on every stock.

  • Real-time prices, no delay
  • Every line of DNLI's score, with the points and the reason
  • All 14 checks on DNLI and on all 2,958 stocks
  • Every stock ranked, with the chart
  • Every filing, and optional alerts on DNLI
BreakawaySep 9Peter Scott Chin sold DNLI$37K at $22.29, filed Sep 9

What a filing on DNLI would have sent. Alerts are optional.

See all 14 checks on DNLIFree for 24 hours. No account needed. Then keep going with a free account.
Questions

Straight Answers.

Are the prices delayed?

Only on the public pages, which run at least 15 minutes behind. Pro members, trial included, see real-time prices: the scanner refreshes every 15 seconds, and your watchlist every few seconds, pre-market and after hours included.

Where does the data come from?

Daily bars, quotes, reference data, headlines, and short interest come from Massive, formerly Polygon, a licensed market data vendor. The age of the quotes is shown at the top of every page. Insider trades, notable holders and profits come straight from the SEC. That means Form 4 filings, 13F filings and XBRL financial data on EDGAR. Government filings come from the public STOCK Act and Office of Government Ethics disclosures. The market-wide headlines on the market line also come from the public headline feeds CNBC, MarketWatch and Yahoo Finance publish, shown as the headline, the source and a link to the article. Splits, dividends, and the financial statements on each ticker page come from the vendor's reference data. The 8-K filings on EDGAR are read for the items that move a price. Five years of history is loaded for every stock. So the 200-day and 52-week checks rest on real history. Options flow is not part of the product.

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Is this investment advice?

No. It is a screening tool that scores stocks on the chart, the company's own results, and the news and filings. It does not know your situation and it is not a recommendation to buy or sell anything. Please do your own research.

The price, the score, the chart checks and readings, and the industry rank on this page are delayed at least 15 minutes. Filings are shown as filed, because a disclosure is already days or weeks old when it becomes public. Earnings dates and past reactions are settled sessions.