Prelude Therapeutics (PRLD) logo

Prelude Therapeutics (PRLD) stock

Cancer medicines , market cap $287M

$3.70
+1.93%

As of Monday's close · Live for Pro members at the open

Quality Score
3
Below Average
In its industry
#94of 291

PRLD's Quality Score rose 1 point on Mon, Oct 26, to 3. Buying volume reached a 20-day high.

Follow PRLD's trial news. Pro members can get an alert when Prelude Therapeutics files news, and see its trials, share raises, and its CEO's filings.

Get an alert when PRLD files news on its trialSee it live, free until Wednesday morning. No account. No card. Then keep going with a free account.

We do the work for you. Every stock is scored and ranked, every 15 seconds while the market is open. Here it's 15 minutes behind. Pro members see it live.

NextQ4 2026“…in patients with HR+ breast cancer anticipated to begin enrolling patients in the fourth quarter of 2026…”Trial start · SEC filing · Sep 10
Cash$152M in cash. One of the last four quarters brought cash in while the others used it.On Jun 30 · the company says “into the second quarter of 2028”

Why is PRLD down?

Down 45% from its Aug 21, 2026 high.

  • It filed a prospectus for an offering of shares on Apr 21, 2026, its newest of 2 offering filings.

Sources: Price history, Oct 23, 2026; Prospectus supplement, Apr 21, 2026

2 more reasons why PRLD is down from its high, from its filings, with the other side, how the business stands, the timeline, and its peers, for Pro members.

Key facts on PRLD

Key facts on PRLD
Holding it back29.5% more shares than a year ago
Latest filing10-Q, Aug 11 Filed its quarterly report (10-Q) for the quarter to Jun 30, 2026

6 more reasons behind PRLD's 3, for Pro members.

Cash$152M in cash. One of the last four quarters brought cash in while the others used it.On Jun 30 · the company says “into the second quarter of 2028”

PRLD catalysts

Coming up

After its last 4 reports it closed +8.1% on average, higher 3 of 4 times.

1 past catalyst since 2026, with sizes and sources, for Pro members.Get in free →

What's next for PRLD, and how long its cash lasts

Next step the company has named

Q4 2026“Phase 1 study of PRT13722 in patients with HR+ breast cancer anticipated to begin enrolling patients in the fourth quarter of 2026.”Trial start · SEC filing · Sep 10

What it means: when a trial begins, or reaches the stage the company named.

Lead program
PRT13722
Another trial
PRT12396 in Participants With Select Myeloproliferative NeoplasmsPhase 1 · Recruiting · 100 people · main data estimated Apr 2028 · NCT07469891

For Pro members: 36 filings.

Cash runway Jun 30 balance sheet

$152M in cash

One of the last four quarters brought cash in while the others used it, so an average says little about the next.

What it means: a runway is counted only when each of the last four quarters used cash. The company's estimate is “into the second quarter of 2028” (8-K, Aug 11).

For Pro members: the cash used each quarter, and the math.

Dilution on the horizon

  • Shelf registration (S-3, filed May 30, 2024)
  • At-the-market share sales program (424B5, filed Mar 12, 2026)

For Pro members: 2 raises and their amounts, and the share count against a year ago.

Insiders

Director David P Bonita bought 2,815,315 shares on Apr 21. 1 more insider trade this year.

From Form 4: open-market buys and sales only.

For Pro members: every trade, and Krishna Vaddi’s 17 filings and quotes.

Get an alert when PRLD files news on its trialSee it live, free until Wednesday morning. No account. No card. Then keep going with a free account.

See every upcoming FDA date →

FDA dates in the next 60 days

Decision dates and advisory committee meetings the companies have announced in their filings, soonest first and small companies first.

DateStockDrug

10 more FDA dates and 103 trial data dates in the next 60 days, each on the FDA calendar. Pro members see whether each company's cash lasts past its date, with an optional alert before it. See all 168 dates, ranked →

Why PRLD scores 3

Below AverageTrending up, 5 of 14 chart checks firingWhat the Quality Score means

  • +5Chart checks 5 of 14 firing right now, one point each
  • +2Run-up 147% over 12 months
  • Long-term trend subtracts
  • Size subtracts
  • Growth addsSales and margins against a year earlier: up to +3 for fast growth and widening margins, down to -2 when both shrink.
  • Dilution subtractsNew shares over the year: -1 at 10% more, -2 at 25% more.
  • Volatility subtractsA daily range of 5% or more with nothing behind it (no profit or cash flow, sales shrinking, or 10% more shares outstanding with no free cash flow): -1, or -2 from 8%.
  • Cash flow subtracts-1 when free cash flow over the last four quarters is negative.

No effect today: Profit, Persistence, and News.

What every line is worth, and the reason behind it, on PRLD and every other stock.Get in free →

Price, score, chart checks, and the industry rank are from a snapshot taken at 10:16 PM ET, at least 15 minutes behind. How we rank stocks.

Tested. Our top-⁠scored stocks returned 2.2x the average stock over the next month. How we tested it

Alert me when PRLD's Quality Score turns up

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Here is what Pro members see.

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    Price action, the company, and signals, each with its points, on PRLD and every other stock.

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  • Congress trades

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  • 14 chart checks, read for you

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PRLD has 5 of 14 chart checks firing

Volume1 of 3 shown
Tight range1 of 3 shown
Buying1 of 3 shown
The other 10 checks on PRLD, and all 14 on every stock.Get in free →

PRLD RSI today: 44.2, below its 50-day and 200-day averages

Not scored

Not in the Quality Score: over 20 years of tests, 2006 to 2026, they added no edge.

The deep dive on PRLD

4 more findings on PRLD, each with its source, for Pro membersGet in free →

How PRLD ranks in Biotech

PRLD is #94 of 291 by Quality Score.

How PRLD ranks in Biotech
94Prelude Therapeutics (PRLD) logoPRLDPrelude Therapeutics3

More in Biotech

When does PRLD report earnings, and what happens after?

Expected to report Wed Nov 11, before the open (in 16 days). Expected.

What an earnings report is: every 3 months, a company tells everyone how much it sold and earned. We read the figures, the outlook, and how the stock moved after.

What PRLD reported on Aug 11, 2026

The quarter

The figures are not read from the release yet.

“Along with the decrease in stock-based compensation expense, the decrease was primarily related to lower expense incurred for our SMARCA2 clinical trials which we paused in 2025 along with a decrease in employee related expenses due to a workforce reduction in the second half of 2025.”

The filing on EDGAR

Where the sales came from

PRLD's results filing gives no sales by line in a table we read.

The outlook

No outlook figures read from this release.

In the company's words

  • “The decrease in general and administrative expenses was primarily due to a decrease in stock-based compensation along with a decrease in employee-related expenses.”

From its results filing (SEC filing · Aug 11)

The numbers

Market value
$287M
today
Sales
$22.4M
up 220% on the year
Free cash flow
-$33.3M
last 12 months

2 more figures, for Pro members.

No analyst estimates on Breakaway: every figure here is filed.

The whole report on PRLD: every line of its sales, every outlook beside the one it replaced, and the company's words, for Pro members.Get in free →
ReportedGapReaction5
sessions
Aug 11, 2026Before open+2.5%+10.1%+16.6%
May 12, 2026Before open0.0%-3.3%-9.6%
Mar 10, 2026Before open-3.2%+16.5%+8.7%

PRLD closed higher after 3 of its last 4 reports.

All 4 reports, and PRLD's Quality Score going into each

PRLD share count over time

Shares: 29.5% more than a year ago (to Jun 30).

Shares of PRLD outstanding, as filed
Shares
outstanding
As
of
79.8MAug 6, 2026
79.6MMay 7, 2026
63MMar 6, 2026
62.9MNov 10, 2025
Offerings, shelves, and splits of PRLD, from its filings
From its
filings
Filed
Priced a sale of sharesApr 21, 2026
Set up an at-the-market program for up to $25M of shares, about 9% of its market valueMar 12, 2026
Registered shares for a later sale (S-3)Dec 10, 2025
Registered shares for a later sale (S-3)May 30, 2024

1 more offering on file, for Pro members.

Which ETFs hold PRLD?

In ETFs: PRLD is under 0.1% of VTI, the most of the 24 funds Breakaway covers, by their holdings as filed for Jun 30, 2026.

About Prelude Therapeutics

Prelude Therapeutics Incorp is a precision oncology company developing medicines in areas of high unmet need for cancer patients. Its pipeline features selective KAT6A degraders and mutant selective JAK2V617F JH2 inhibitors, new approaches to clinically validated targets with transformative potential for patients. The company is also leveraging its expertise in targeted protein degradation to discover and develop next-generation degrader antibody conjugates (DACs) with novel payloads.

79 employeesWilmington, DEpreludetx.com

What Prelude Therapeutics says it competes with

“We face competition from segments of the pharmaceutical, biotechnology and other related markets that pursue the development of precision oncology therapies optimized to target the key driver mechanisms in cancers with high unmet need.”

From its annual report, SEC filing · Mar 10, 2026

2 more sentences and what it says it does, for Pro membersGet in free →

PRLD's score card

Prelude Therapeutics (PRLD): Quality Score 3, Below Average, #94 of 291 in Biotech, with its price, on Breakaway
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  • What would turn PRLD's score around: 8 things
  • 6 more filings explained, a plain line each
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See PRLD's 14 chart checks

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Straight Answers

As of Oct 26, 2026: PRLD's Quality Score is 3 (Below Average), #94 of 291 in Biotech.

Is PRLD a good stock to buy? What its Quality Score says

PRLD scores 3 today, which Breakaway calls Below Average. It is #94 of 291 in Biotech by Quality Score, with 5 of 14 chart checks firing. Down 45% from its Aug 21, 2026 high. Shares: 29.5% more than a year ago (to Jun 30). Breakaway does not say whether to buy any stock: the score does not know your situation, and it is not a recommendation to buy or sell anything. Please do your own research.

What is PRLD's Quality Score?

PRLD scores 3 today, which Breakaway calls Below Average (0 to 5). That is #94 of 291 in Biotech by Quality Score. The score adds up the chart checks, the trend, the company's filed sales, its profits, the news, insider trades, and Congress trades. The section above lists the lines behind PRLD's 3.

When does PRLD report earnings?

Expected to report Wed Nov 11, before the open, a date Breakaway expects from the company's usual timing; the company has not confirmed it. PRLD closed higher after 3 of its last 4 reports. Past behavior, not a forecast.

Are the prices delayed?

Only on the public pages, which run at least 15 minutes behind. Pro members, and anyone on a guest pass, see real-time prices: the scanner refreshes every 15 seconds, and your watchlist every few seconds, pre-market and after hours included.

What's next for Prelude Therapeutics: from its SEC filings and ClinicalTrials.gov, the company's words, the registry's dates, and arithmetic, not a forecast. Companies often miss the dates they set.

The moves after past earnings reports are past behavior, not a forecast.

The price, the score, the chart checks and readings, and the industry rank on this page are delayed at least 15 minutes.

Our top-scored stocks' record: Oct 2021 to Sep 2026, before costs; recorded live since Sep 9 2026.

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